Released research with codeine have noted inconsistent results and have crucial methodological restrictions (see Information). You will discover reports of respiratory despair when codeine is employed for the duration of labor and shipping and delivery (see Clinical Concerns).
The codeine and promethazine in Promethazine with Codeine Oral Answer may enhance the frequency of seizures in sufferers with seizure Issues, and could improve the chance of seizures occurring in other clinical configurations connected to seizures.
Endocrine/Metabolic: Conditions of serotonin syndrome, a possibly everyday living-threatening issue, are claimed throughout concomitant use of opioids with serotonergic medicines.
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Promethazine with Codeine Oral Option should be employed with caution in sufferers with critical impairment of renal purpose, and people ought to be monitored intently for respiratory despair, sedation, and hypotension.
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Hypotension Tell patients that Promethazine with Codeine Oral Alternative may possibly trigger orthostatic hypotension and syncope. Instruct patients how to acknowledge signs of reduced hypertension and how to lower the risk of major repercussions should hypotension happen (e.
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